Comparison of the antioxidant potential in urine, saliva and skin

被引:1
作者
Benkhai, Hicham [1 ]
Koehler, Franziska [1 ]
Lademann, Juergen [2 ]
Lemanski, Sandra [3 ]
Bornewasser, Manfred [3 ]
Below, Elke [4 ]
Below, Harald [1 ]
Kramer, Axel [1 ]
机构
[1] Univ Med Greifswald, Inst Hyg & Environm Med, Walter Rathenau Str 49 A, D-17475 Greifswald, Germany
[2] Charite Univ Med Berlin, Dept Dermatol & Allergol, Berlin, Germany
[3] Ernst Moritz Arndt Univ Greifswald, Inst Psychol, Greifswald, Germany
[4] Ernst Moritz Arndt Univ Greifswald, Inst Forens Sci, Greifswald, Germany
来源
GMS HYGIENE AND INFECTION CONTROL | 2011年 / 6卷 / 01期
关键词
antioxidant potential; free radicals; oxidative stress; beta-carotene; reactive oxygen species; urine; saliva; photochemoluminescence; antioxidants;
D O I
10.3205/dgkh000159
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Aim: Free radicals, oxidative stress and their possible consequences for health are becoming increasingly important in modern medicine. Reactive species influence the organism, potentially causing oxidative cell damage. They can be produced by exogenous sources, or be a product of a variety of not only physiological metabolic processes, such as immune response, but also pathological processes. The antioxidant protection system protects the organism from oxidative damage caused by reactions producing an excess of free radicals. The analysis of antioxidant potential (AOP) is therefore becoming increasingly important for the diagnosis of individual vitality. Method: The photochemoluminescence method was used to measure the AOP in urine and saliva, spectrometry was employed to measure the beta-carotene content of the skin. In addition, it was investigated whether the AOP saliva correlated with the AOPU urine (uric-acid independent AOP) as well as the beta-carotene content of the skin. Results: The AOP was significantly higher in urine than in saliva, and both values were significantly positively correlated with each other. However, there was no significant correlation to the beta-carotene content of the skin. Discussion: The components of the AOPU urine are accumulated over time (night), whereas AOP measurement in saliva is like a snapshot, which explains why AOPU urine was significantly higher than AOP saliva, although the two parameters are correlated with each other. beta-carotene is a fatsoluble antioxidant, whereas in our study, only water-soluble antioxidants were determined in the urine. This explains why there is no positive correlation between beta-carotene of the skin and AOP. Conclusion: For the characterization of the AOP in epidemiological studies, we recommend determining the AOPU urine and parallel to this, the beta-carotene content of the skin.
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页数:4
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