EVIDENCE FOR INVOLVEMENT OF N-METHYL-D-ASPARTATE RECEPTOR IN TONIC INHIBITORY CONTROL OF DOPAMINERGIC TRANSMISSION IN RAT MEDIAL FRONTAL-CORTEX

被引：43

作者：

HATA, N ^{[1
]}

NISHIKAWA, T ^{[1
]}

UMINO, A ^{[1
]}

TAKAHASHI, K ^{[1
]}

机构：

[1] NATL CTR NEUROBIOL PSYCHIAT, NATL INST NEUROSCI, DIV MENTAL DISORDER RES, KODAIRA, TOKYO 187, JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 120卷 / 01期

关键词：

3,4-Dihydroxyphenylacetic acid; Dopamine; Dopamine utilization; Excitatory amino acidergic transmission; Medial frontal cortex; N-Methyl-d-aspartate receptor; Norepinephrine utilization;

D O I：

10.1016/0304-3940(90)90178-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bilateral infusion of dl-2-amino-5-phosphonovalerate (dl-APV) (which is a competitive antagonist for N-methyl-d-aspartate (NMDA) receptor) into the medial frontal cortex of conscious rats increased the amount of 3,4-dihydroxyphenylacetic acid (DOPAC) and the DOPAC/dopamine (DA) ratio in the cortical area. Moreover, intra-prefrontal injection of dl-APV, d-APV, dl-2-amino-7-phosphonoheptanoate and 3-[(±)-2-carboxypiperazin-4-yl]-propyl-1-phosphonate (which are selective NMDA receptor antagonists), but not the l-isomer of APV and γ-glutamyl-aminomethyl sulphonate (a relative antagonist for non-NMDA receptors), facilitated prefrontal DA utilization in a NMDA-reversible manner. These findings suggest that NMDA-type excitatory amino acid receptors may be involved in a tonic inhibitory regulation of dopaminergic transmission in the medial frontal cortex in vivo. © 1990.

引用

页码：101 / 104

页数：4