SURFACE-ACTIVITY AND SELF-ASSOCIATION OF SOME BETA-ADRENOCEPTOR BLOCKING-AGENTS IN AQUEOUS-SOLUTION

被引：28

作者：

ATTWOOD, D

AGARWAL, SP

机构：

[1] Pharmacy Department, University of Manchester, Manchester

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1979年 / 31卷 / 06期

关键词：

D O I：

10.1111/j.2042-7158.1979.tb13530.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The surface activity at the air‐solution interface of a series of β‐adrenoceptor blocking agents has been determined. The drugs investigated included, propranolol, sotalol, oxprenolol, labetolol, timolol, metoprolol and acebutolol. Correlation between surface activity and local anaesthetic potency of the drugs is examined. Light scattering measurements have indicated self‐association of sotalol, oxprenolol, acebutolol and metoprolol in 0.5 mol kg−1 sodium chloride. Critical micelle concentrations and aggregation numbers are reported. 1979 Royal Pharmaceutical Society of Great Britain

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收藏

页码：392 / 395

页数：4

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