NISOXETINE ANTAGONISM OF NOREPINEPHRINE DEPLETION IN BRAIN AND HEART AFTER ALPHA-METHYL-META-TYROSINE ADMINISTRATION

被引：10

作者：

FULLER, RW

SNODDY, HD

PERRY, KW

机构：

[1] The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

NEUROPHARMACOLOGY | 1979年 / 18卷 / 10期

关键词：

D O I：

10.1016/0028-3908(79)90020-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nisoxetine hydrochloride (5-40 mg/kg i.p.) antagonized the depletion of norepinephrine in brain and heart following the injection of α-methyl-m-tyrosine (6.25-100 mg/kg, s.c.) into rats and mice. In rats. the degree of antagonism was directly related to the dose of nisoxetine and inversely related to the dose of α-methyl-m-tyrosine. Associated with the antagonism by nisoxetine of norepinephrine depletion by α-methyl-m-tyrosine was a reduction in the tissue concentration of metaraminol, the metabolite of α-methyl-m-tyrosine whose retention in nerve terminals probably accounts for the depletion of norepinephrine. Similar antagonism of norepinephrine depletion and lowering of metaraminol concentration by nisoxetine was observed in brain and heart after the injection of metaraminol itself. These findings extend previous data showing the effectiveness of nisoxetine as an inhibitor of uptake into norepinephrine neurons in vitro. © 1979.

引用

页码：767 / 770

页数：4

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