THE PHARMACOKINETICS OF INDORAMIN AND 6-HYDROXYINDORAMIN IN POOR AND EXTENSIVE HYDROXYLATORS OF DEBRISOQUINE

被引:23
作者
PIERCE, DM
SMITH, SE
FRANKLIN, RA
机构
[1] WYETH LABS,DRUG METAB & PHARMACOKINET SECT,MAIDENHEAD SL6 0PH,BERKS,ENGLAND
[2] ST THOMAS HOSP,SCH MED,DEPT CLIN PHARMACOL,LONDON SE1 7EH,ENGLAND
关键词
D O I
10.1007/BF00610381
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:59 / 65
页数:7
相关论文
共 16 条
[1]   PHARMACOGENETIC COVARIATION OF DEFECTIVE N-OXIDATION OF SPARTEINE AND 4-HYDROXYLATION OF DEBRISOQUINE [J].
BERTILSSON, L ;
DENGLER, HJ ;
EICHELBAUM, M ;
SCHULZ, HU .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 17 (02) :153-155
[2]  
DELAUNOIS AL, 1973, BIOSTATISTICS PHARM, V2, P889
[3]  
FRANKLIN RA, 1981, XENOBIOTICA, V11, P755
[4]   STUDIES ON THE METABOLISM OF THE NEW ANTI-HYPERTENSIVE AGENT, INDORAMIN, IN MAN [J].
FRANKLIN, RA ;
ROBSON, P ;
STEVENSON, D .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 24 (05) :629-634
[5]  
IDLE JR, 1979, BRIT J PHARMACOL, V66, pP430
[6]   POLYMORPHISMS OF OXIDATION AT CARBON CENTERS OF DRUGS AND THEIR CLINICAL SIGNIFICANCE [J].
IDLE, JR ;
SMITH, RL .
DRUG METABOLISM REVIEWS, 1979, 9 (02) :301-317
[7]   DIFFERENTIAL STEREOSELECTIVE METABOLISM OF METOPROLOL IN EXTENSIVE AND POOR DEBRISOQUIN METABOLIZERS [J].
LENNARD, MS ;
TUCKER, GT ;
SILAS, JH ;
FREESTONE, S ;
RAMSAY, LE ;
WOODS, HF .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1983, 34 (06) :732-737
[8]   POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN [J].
MAHGOUB, A ;
IDLE, JR ;
DRING, LG ;
LANCASTER, R ;
SMITH, RL .
LANCET, 1977, 2 (8038) :584-586
[9]   PHARMACOKINETICS OF ORAL INDORAMIN IN ELDERLY AND MIDDLE-AGED FEMALE VOLUNTEERS [J].
NORBURY, HM ;
FRANKLIN, RA ;
MARROTT, PK ;
WARRINGTON, SJ .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 27 (02) :247-249
[10]   PHARMACOKINETICS OF INTRAVENOUS INDORAMIN IN MIDDLE-AGED MALE AND FEMALE VOLUNTEERS [J].
NORBURY, HM ;
FRANKLIN, RA ;
MARROTT, PK ;
WARRINGTON, SJ .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 25 (02) :243-246