Rasburicase-induced methemoglobinemia: case report, literature review, and proposed treatment algorithm

被引：26

作者：

Sherwood, Garrett B. ^{[1
]}

Paschal, Rita D. ^{[2
]}

Adamski, Jill ^{[3
]}

机构：

[1] Univ Alabama Birmingham, Birmingham, AL USA

[2] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[3] Mayo Clin, Dept Lab Med & Pathol, Scottsdale, AZ USA

来源：

CLINICAL CASE REPORTS | 2016年 / 4卷 / 04期

关键词：

Hemolytic anemia; methemoglobinemia; rasburicase; tumor lysis syndrome;

D O I：

10.1002/ccr3.495

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Key Clinical Message Rasburicase for the treatment of tumor lysis syndrome has been associated with hemolytic anemia and methemoglobinemia, usually in patients with G6PD deficiency. Risks and benefits should be considered prior to use of rasburicase in at-risk patients. Methylene blue will worsen the hemolytic anemia in G6PD deficiency and should be avoided.

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收藏

页码：315 / 319

页数：5

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