GASTROPROTECTIVE EFFECT OF ZINC-SULFATE IN ETHANOL-INDUCED ULCEROGENESIS IN RATS

被引：0
|
作者：
TRAPKOV, VA [1 ]
GOBEDZHASHVILI, SD [1 ]
ERZINKYAN, KL [1 ]
机构：
[1] RUSSIAN SCI CTR SAFETY BIOL ACT SUBST,CORRECT METAB DISORDERS LAB,STARAYA KUPAVNA,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 119卷 / 01期
关键词：
GASTROPROTECTIVE ACTIVITY; ZINC SULFATE; ETHANOL-INDUCED ULCEROGENESIS; PROSTAGLANDINS;
D O I：
10.1007/BF02445927
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In a rat model of ethanol-induced peptic ulcer it is demonstrated that pretreatment with zinc sulfate (intragastral administration) lowers the ethanol-induced damage to the gastral mucosa in a dose-dependent manner. Subcutaneous injection of indomethacin has no appreciable effect on the gastroprotective effect of zinc. It is assumed that the gastroprotective effect of zinc sulfate is not mediated by the release of endogenous prostaglandins.
引用
收藏
页码：43 / 44
页数：2
相关论文
共 50 条
  • [31] Acute Toxicity and Gastroprotective Effect of 2-pentadecanone in Ethanol-induced Gastric Mucosal Ulceration in Rats
    Kamran, Sareh
    Karimian, Hamed
    Salehen, Nurain
    Khalajhedayati, Atin
    Razak, Bushroa Abdul
    Majid, Nazia Abdul
    INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2019, 15 (08) : 944 - 952
  • [32] Gastroprotective effect of lupeol on ethanol-induced gastric damage and the underlying mechanism
    De S. Lira S.R.
    Rao V.S.
    Carvalho A.C.S.
    Guedes M.M.
    De Morais T.C.
    De Souza A.L.
    Trevisan M.T.S.
    Lima A.F.
    Chaves M.H.
    Santos F.A.
    Inflammopharmacology, 2009, 17 (4) : 221 - 228
  • [33] THE EFFECTS OF ZINC-SULFATE ON HYPERCHOLESTEROLEMIA INDUCED BY CHOLESTEROL-CHOLEATE IN RATS
    CHO, CH
    CHEN, SM
    OGLE, CW
    PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1985, 17 (05): : 433 - 438
  • [34] Antioxidant effect of zinc chloride against ethanol-induced gastrointestinal lesions in rats
    Ineu, Rafael Porto
    Oliveira, Claudia Sirlene
    Oliveira, Vitor Antunes
    Moraes-Silva, Lucelia
    Almeida da Luz, Sonia Cristina
    Pereira, Maria Ester
    FOOD AND CHEMICAL TOXICOLOGY, 2013, 58 : 522 - 529
  • [35] THE EFFECT OF ZINC-SULFATE ON HERPES LABIALIS
    POLENIK, P
    6TH INTERNATIONAL TRACE ELEMENT SYMP 1989, VOLS 1-5, 1989, : 680 - 683
  • [36] EFFECT OF FOODSTUFFS ON ABSORPTION OF ZINC-SULFATE
    PECOUD, A
    DONZEL, P
    SCHELLING, JL
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1975, 17 (04) : 469 - 474
  • [37] Gastroprotective Effects of Various Scrophularia striata Extracts on Ethanol-Induced Gastric Ulcer in Rats
    Rafiei, Maryam
    Namazi, Fatemeh
    Rajaian, Hamid
    Nazifi, Saeed
    TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 13 (03) : 328 - 334
  • [38] Gastroprotective effects of Tunisian green clay on ethanol-induced gastric mucosal lesion in rats
    Ben Ali, Ridha
    Ounis, Anouar
    Ben Said, Dorra
    Dziri, Chadli
    El May, Michele Veronique
    APPLIED CLAY SCIENCE, 2017, 149 : 111 - 117
  • [39] Gastroprotective property of Pseudocydonia sinensis fruit jelly on the ethanol-induced gastric lesions in rats
    Hamauzu, Yasunori
    Kishida, Hiyo
    Yamazaki, Nozomi
    JOURNAL OF FUNCTIONAL FOODS, 2018, 48 : 275 - 282
  • [40] Gastroprotective Activity of Methyleugenol from Peperomia hispidula on Ethanol-Induced Gastric Lesions in Rats
    Elena Sanchez-Mendoza, Maria
    Cruz-Antonio, Leticia
    Arrieta-Baez, Daniel
    Maria Olivares-Corichi, Ivonne
    Rojas-Martinez, Raul
    Martinez-Cabrera, Dorismilda
    Arrieta, Jesus
    INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2015, 11 (07) : 697 - 704
12345