GASTROPROTECTIVE EFFECT OF ZINC-SULFATE IN ETHANOL-INDUCED ULCEROGENESIS IN RATS

被引：0
|
作者：
TRAPKOV, VA [1 ]
GOBEDZHASHVILI, SD [1 ]
ERZINKYAN, KL [1 ]
机构：
[1] RUSSIAN SCI CTR SAFETY BIOL ACT SUBST,CORRECT METAB DISORDERS LAB,STARAYA KUPAVNA,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 119卷 / 01期
关键词：
GASTROPROTECTIVE ACTIVITY; ZINC SULFATE; ETHANOL-INDUCED ULCEROGENESIS; PROSTAGLANDINS;
D O I：
10.1007/BF02445927
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In a rat model of ethanol-induced peptic ulcer it is demonstrated that pretreatment with zinc sulfate (intragastral administration) lowers the ethanol-induced damage to the gastral mucosa in a dose-dependent manner. Subcutaneous injection of indomethacin has no appreciable effect on the gastroprotective effect of zinc. It is assumed that the gastroprotective effect of zinc sulfate is not mediated by the release of endogenous prostaglandins.
引用
收藏
页码：43 / 44
页数：2
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