SYNTHESIS AND BIOLOGICAL EVALUATION OF 4-DEACETOXYPACLITAXEL

被引：32

作者：

CHORDIA, MD

CHAUDHARY, AG

KINGSTON, DGI

JIANG, YQ

HAMEL, E

机构：

[1] VIRGINIA POLYTECH INST & STATE UNIV,DEPT CHEM,BLACKSBURG,VA 24061

[2] NCI,DIV CANC TREATMENT,MOLEC PHARMACOL LAB,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 37期

关键词：

D O I：

10.1016/0040-4039(94)85019-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Deacetoxypaclitaxel (9) has been prepared in seven steps from paclitaxel (Taxol(R)). It is significantly less active than paclitaxel in tubulin-assembly and cytotoxicity bioassays.

引用

页码：6843 / 6846

页数：4

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