FARNESYL DIPHOSPHATE SYNTHASE REACTIONS OF GERANYL DIPHOSPHATE ANALOGS HAVING OXYGEN-ATOMS IN THEIR ALKYL CHAINS

被引：7

作者：

MAKI, Y ^{[1
]}

SATOH, H ^{[1
]}

KURIHARA, M ^{[1
]}

ENDO, T ^{[1
]}

WATANABE, G ^{[1
]}

OGURA, K ^{[1
]}

机构：

[1] TOHOKU UNIV, INST CHEM REACT SCI, SENDAI, MIYAGI 980, JAPAN

来源：

CHEMISTRY LETTERS | 1994年 / 10期

关键词：

D O I：

10.1246/cl.1994.1841

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Seven geranyl diphosphate analogues having oxygen atoms in their alkyl chains were synthesized and examined for their reactivities as substrates in the reaction catalyzed by pig liver farnesyl diphosphate synthase. All of these compounds acted as substrates to give farnesyl diphosphate analogues. It was suggested that the enzyme cavity for the geranyl moiety is tolerant enough to accommodate alkyl moieties containing oxygen atoms.

引用

页码：1841 / 1844

页数：4

共 19 条

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MAKI, Y
KURIHARA, M
ENDO, T
ABIKO, M
SAITO, K
WATANABE, G
OGURA, K
CHEMISTRY LETTERS, 1995, (05) : 389 - 390
[2] Farnesyl Diphosphate Synthase Reactions with Dimethylallyl Diphosphate Analogues Having Oxygen Atoms in Their Chains
Maki, Y.
Kurihara, M.
Endo, T.
Abiko, M.
Chemistry Letters, (05):
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[4] FARNESYL DIPHOSPHATE SYNTHASE AND SOLANESYL DIPHOSPHATE SYNTHASE REACTIONS OF DIPHOSPHATE-MODIFIED ALLYLIC ANALOGS - THE SIGNIFICANCE OF THE DIPHOSPHATE LINKAGE INVOLVED IN THE ALLYLIC SUBSTRATES FOR PRENYLTRANSFERASE
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JOURNAL OF BIOCHEMISTRY, 1992, 112 (01): : 20 - 27
[5] Bisubstrate analogs and inhibitors of the enzyme farnesyl diphosphate synthase
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[6] Substrate specificity of thermostable farnesyl diphosphate synthase with alkyl group homologs of isopentenyl diphosphate
Nagaki, M
Kannari, H
Ishibashi, J
Maki, Y
Nishino, T
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (18) : 2549 - 2554
[7] Functional characterization of geranyl/farnesyl diphosphate synthase in Wurfbainia villosa and Wurfbainia longiligularis
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Zhan, Ruoting
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Yang, Peng
PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2024, 212
[8] Characterization of a novel aphid prenyltransferase displaying dual geranyl/farnesyl diphosphate synthase activity
Vandermoten, Sophie
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Santini, Sebastien
Sen, Stephanie E.
Beliveau, Catherine
Vandenbol, Micheline
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FEBS LETTERS, 2008, 582 (13): : 1928 - 1934
[9] Structural features conferring dual Geranyl/Farnesyl diphosphate synthase activity to an aphid prenyltransferase
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[10] Partial purification and characterization of the short-chain prenyltransferases, geranyl diphosphate synthase and farnesyl diphosphate synthase, from Abies grandis (grand fir)
Tholl, D
Croteau, R
Gershenzon, J
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2001, 386 (02) : 233 - 242

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