INHIBITION OF SOLUBLE CATECHOL-O-METHYLTRANSFERASE AND SINGLE-DOSE PHARMACOKINETICS AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF ENTACAPONE

被引：3
|
作者：
KERANEN, T
GORDIN, A
KARLSSON, M
KORPELA, K
PENTIKAINEN, PJ
RITA, H
SCHULTZ, E
SEPPALA, L
WIKBERG, T
机构：
[1] TAMPERE UNIV HOSP,DEPT NEUROL,TAMPERE,FINLAND
[2] ORION FARMOS PHARMACEUT,ORION RES CTR,ESPOO,FINLAND
[3] HELSINKI UNIV,DEPT MED 3,HELSINKI,FINLAND
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1994年 / 46卷 / 02期
关键词：
ENTACAPONE; CATECHOL-O-METHYLTRANSFERASE; PHARMACOKINETICS; HEALTHY VOLUNTEERS; ADVERSE EFFECTS; METABOLISM;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The inhibition of soluble catechol-O-methyl-transferase (S-COMT) in red blood cells (RB Cs) by entacapone, and the pharmacokinetics of entacapone after single oral (5-800 mg) and IV (25 mg) doses have been examined in an open study in 12 healthy young male volunteers.
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页码：151 / 157
页数：7
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