ANTIBODY-RESPONSES TO 4-CORNERS-HANTAVIRUS INFECTIONS IN THE DEER MOUSE (PEROMYSCUS-MANICULATUS) - IDENTIFICATION OF AN IMMUNODOMINANT REGION OF THE VIRAL NUCLEOCAPSID PROTEIN

被引：74

作者：

YAMADA, T

HJELLE, B

LANZI, R

MORRIS, C

ANDERSON, B

JENISON, S

机构：

[1] UNIV NEW MEXICO, SCH MED, DEPT MED, ALBUQUERQUE, NM 87131 USA

[2] UNIV NEW MEXICO, SCH MED, DEPT PATHOL, ALBUQUERQUE, NM 87131 USA

[3] UNIV NEW MEXICO, SCH MED, DEPT MICROBIOL, ALBUQUERQUE, NM 87131 USA

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 03期

关键词：

D O I：

10.1128/JVI.69.3.1939-1943.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibody responses to Four Corners hantavirus (FCV) infections in the deer mouse (Peromyscus maniculatus) were characterized by using FCV nucleocapsid protein (N), glycoprotein 1 (G1), and glycoprotein 2 (G2) recombinant polypeptides in Western immunoblot assays. Strong immunoglobulin G reactivities to FCV N were observed among FCV-infected wild P. maniculatus mice (n = 34) and in laboratory-infected P. maniculatus mice (n = 11). NO immunoglobulin G antibody reactivities to FCV G1 or G2 linear determinants were detected. The strongest N responses were mapped to an amino-proximal segment between amino acids 17 and 59 (QLVTARQKLKDAERAVELDPDDVNKSTLQSRRAAVSALETKLG). FCV N antibodies cross-reacted with recombinant N proteins encoded by Puumala, Seoul, and Hantaan viruses.

引用

页码：1939 / 1943

页数：5

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