DOSE, TIME AND ROUTE DEPENDENCY OF THE INDUCTION OF RAT HEPATIC ORNITHINE DECARBOXYLASE BY 12-TETRADECANOYLPHORBOL 13-ACETATE

被引：2

作者：

MITRA, A ^{[1
]}

RICHARDS, I ^{[1
]}

KULKARNI, AP ^{[1
]}

机构：

[1] UNIV S FLORIDA,COLL PUBL HLTH,TOXICOL PROGRAM,MHH-104,TAMPA,FL 33620

来源：

DRUG AND CHEMICAL TOXICOLOGY | 1992年 / 15卷 / 01期

关键词：

D O I：

10.3109/01480549209035173

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ornithine decarboxylase (ODC) activity, the rate limiting enzyme in polyamine biosynthesis, was determined after 12-O-tetradecanoylphorbol 13-acetate (TPA) administration to female Sprauge-Dawley rats. The extent of induction depended on the dose, exposure, time and route of administration. The most effective dose for ODC induction by the intraperitoneal route was 40-mu-g TPA/kg which caused 3-5 fold ODC induction. Maximal ODC induction occurred in a narrow time band 5 hours after TPA administration. TPA had no adverse effects on hepatic DNA (measured by alkaline elution), cytochrome P-450 content and reduced glutathione content or serum alanine aminotransferase (SGPT) activity.

引用

页码：67 / 79

页数：13

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