MODULATION OF THE BEHAVIORAL-EFFECTS OF INTERLEUKIN-1 IN MICE BY NITRIC-OXIDE

被引：28

作者：

BLUTHE, RM

SPARBER, S

DANTZER, R

机构：

[1] INRA,INSERM,U176,RUE CAMILLE ST SAENS,F-33077 BORDEAUX,FRANCE

[2] UNIV MINNESOTA,DEPT PHARMACOL,MINNEAPOLIS,MN 55455

来源：

NEUROREPORT | 1992年 / 3卷 / 02期

关键词：

NITRIC OXIDE; L-ARGININE; INTERLEUKIN-1; SICKNESS BEHAVIOR; BODY WEIGHT; MICE;

D O I：

10.1097/00001756-199202000-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

INTERLEUKIN-1 is a cytokine which mediates the host response to infection and inflammation and is responsible for sickness behaviour. Inhibition of nitric oxide synthase activity by N(omega) nitro-L-Arginine-Methyl-ester (30 mg kg-1, i.p.) potentiated the depressive effects of interleukin-1 (375 ng, i.p.) on social investigation in mice. This effect was attenuated by L-arginine (180 mg kg-1, i.p.) but not by D-arginine. The same treatment did not alter the body weight loss induced by interleukin-1. These results suggest that nitric oxide plays a protective role in the neural effects of interleukin-1.

引用

页码：207 / 209

页数：3

共 15 条

[1] INTERLEUKIN-1 INDUCES PROLONGED L-ARGININE-DEPENDENT CYCLIC GUANOSINE-MONOPHOSPHATE AND NITRITE PRODUCTION IN RAT VASCULAR SMOOTH-MUSCLE CELLS [J].