FLOW CYTOMETRIC ANALYSIS OF CELLULAR DNA CONTENT IN OVARIAN-CANCER

被引：22
|
作者：
HAMAGUCHI, K [1 ]
NISHIMURA, H [1 ]
MIYOSHI, T [1 ]
MIYAHARA, K [1 ]
TATENO, N [1 ]
YAKUSHIJI, M [1 ]
YOKOYAMA, MM [1 ]
机构：
[1] KURUME UNIV,SCH MED,DEPT IMMUNOL,KURUME,FUKUOKA 830,JAPAN
来源：
GYNECOLOGIC ONCOLOGY | 1990年 / 37卷 / 02期
关键词：
D O I：
10.1016/0090-8258(90)90336-J
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A total of 169 paraffin-embedded tissue sections from 42 patients with epithelial ovarian cancer were subjected to analysis of cellular DNA content by flow cytometry. Twenty-three cases were found to be homogenously diploid, whereas 19 cases were aneuploid. A "mosaic" type containing both aneuploid and diploid cell populations was found in 11 of 19 aneuploid cases. Clinical features showed significant correlation with tumor ploidy of FIGO stage and bulky disease. In evaluation of the prognostic value of tumor ploidy, "mosaic" tumors were frequently observed in women who died of disease (DOD), whereas women with diploid tumors survived longer than those with "mosaic" tumors. The present results suggest that determination of DNA heterogeneity may be a valuable parameter in the prognosis of epithelial ovarian Cancer. © 1990.
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收藏
页码：219 / 223
页数：5
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