Mood and Depression Diagnosis in Smoking Cessation

The history of major depressive disorder (MDD), mood at baseline and during quitting, and abstinence at 2 and 52 weeks in 62 smoking treatment patients were examined. Of these participants, 44% were positive for a history of MDD. Depressive history participants had more anger and less vigor at baseline and greater increases in anger and depression during quitting than those without a history. There were significant interactive effects of baseline mood by depression history in predicting abstinence at Week 2 but not at Week 52. Participants with a depression history and who reported greater depression, fatigue, and anger at baseline had lower 2-week abstinence rates than those without a depression history, although not significantly. Participants with a depression history and who reported less depression, fatigue, and anger at baseline had higher 2-week abstinence rates than those without a depression history, although not significantly. Baseline-to-quitting increases in depression were negatively related to 2-week abstinence. Mood during quitting was not significantly related to abstinence at either week.