CD4+ T-LYMPHOCYTOPENIA WITHOUT HIV-INFECTION - INCREASED PREVALENCE AMONG PATIENTS WITH PRIMARY SJOGRENS-SYNDROME

被引:0
作者
KIRTAVA, Z
BLOMBERG, J
BREDBERG, A
HENRIKSSON, G
JACOBSSON, L
MANTHORPE, R
机构
[1] MALMO UNIV HOSP, DEPT RHEUMATOL, SJOGRENS SYNDROME RES CTR, S-20502 MALMO, SWEDEN
[2] MALMO UNIV HOSP, DEPT MED MICROBIOL, S-20502 MALMO, SWEDEN
[3] UNIV LUND HOSP, VIROL SECT, S-22185 LUND, SWEDEN
[4] TBILISI STATE MED UNIV, DEPT CLIN PHARMACOL, TBILISI, GEORGIA
关键词
PRIMARY SJOGRENS SYNDROME; IMMUNOLOGY; T-LYMPHOCYTE SUBSETS IN PERIPHERAL BLOOD; CD4+ T-LYMPHOCYTOPENIA WITHOUT HIV INFECTION; PREVALENCE IN PRIMARY SS; IMMUNODEFICIENCY; AUTOIMMUNE DISEASES;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. Primary Sjogren's syndrome (1 degrees SS) is an autoimmune disease, usually accompanied by manifest immune hyperactivity. In some cases the disease converts to malignant neoplasia. On the other hand, there are clinical similarities to HN infection. Since the I-are phenomenon of persistent depletion of CD4+ T-lymphocytes in peripheral blood without HIV infection was recently defined as idiopathic CD4+ T-lymphocytopenia (ICL), we have used the ICL criteria to investigate the prevalence of this phenomenon among 1 degrees SS patients. Methods. During the period 1988-94, 115 caucasian patients (10 males), mean age 57.8 (range 19 - 82) years, with 1 degrees SS were prospectively studied Lymphocyte subsets were investigated by means of monoclonal antibodies and flow cytometry. For the detection of HIV and HTLV antibodies, we used an enzyme immunoassay (for HIV-1 and HIV-2), Western blot techniques (HN-I, HIV-2, HTLV-I and HTLV-II), and the polymerase chain reaction procedure (HIV-1, HTLV-I and HTLV-II). HN antigens were tested for with the HN-I p-24 Ag test. Results. Six patients with 1 degrees SS fulfilled the criteria for ICL. While the clinical condition of 5 of those six patients remained stable, one patient developed malignant lymphoma three years after her disease was classified as a case of ICL. The prevalence of ICL among our 115 patients with 1 degrees SS was 5.2%, which is significantly higher than the rates reported for arty other patient or population group. We have estimated the relative risk of ICL in 1 degrees SS patients to vary from 3.4 to 6,000 (P values of 0.0001 - 0.025). Conclusion. We suggest that subjects with ICL should be carefully examined for 1 degrees SS and, if its presence is confirmed, that they should be followed with regard to the possible complications of this disease, including the development of malignant lymphoma.
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页码:609 / 616
页数:8
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