HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC STABILITY-INDICATING DETERMINATION OF ZOPICLONE IN TABLETS

被引：17
|
作者：
BOUNINE, JP
TARDIF, B
BELTRAN, P
MAZZO, DJ
机构：
[1] Department of Biological and Chemical Analysis, Institute of Biopharmacy, Rhône-Poulenc Rorer Research and Development
来源：
JOURNAL OF CHROMATOGRAPHY A | 1994年 / 677卷 / 01期
关键词：
D O I：
10.1016/0021-9673(94)80548-2
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A high-performance liquid chromatographic method was developed for the determination of zopiclone in pharmaceutical tablets. The ion-pair reversed-phase method utilizes UV absorbance detection and requires about 15 min per analysis. The known potential degradation products of zopiclone are separated, allowing simultaneous determination. The method was validated for reproducibility, linearity, accuracy and limits of detection.
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页码：87 / 93
页数：7
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