AN LC METHOD FOR MEASURING COMPLEX-FORMATION EQUILIBRIA BY COMPETITIVE CHELATION

被引：11

作者：

CHELLQUIST, EM

SEARLE, R

机构：

[1] Pharmaceutical Sciences, Sterling Winthrop Pharmaceutical Research Division, Collegeville

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 10期

关键词：

HPLC; MRI CONTRAST AGENT; FORMATION CONSTANT; GADOLINIUM;

D O I：

10.1016/0731-7085(93)80059-A

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method, entailing the use of a competitor ligand, is described for measuring complex formation constants by HPLC. The log of the formation constant of Gd(III) 2,6-bis(aminomethyl)pyridinetetraacetate was determined to be 18.6, a previously unreported value.

引用

页码：985 / 992

页数：8