AN LC METHOD FOR MEASURING COMPLEX-FORMATION EQUILIBRIA BY COMPETITIVE CHELATION

被引：11
|
作者：
CHELLQUIST, EM
SEARLE, R
机构：
[1] Pharmaceutical Sciences, Sterling Winthrop Pharmaceutical Research Division, Collegeville
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 10期
关键词：
HPLC; MRI CONTRAST AGENT; FORMATION CONSTANT; GADOLINIUM;
D O I：
10.1016/0731-7085(93)80059-A
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A method, entailing the use of a competitor ligand, is described for measuring complex formation constants by HPLC. The log of the formation constant of Gd(III) 2,6-bis(aminomethyl)pyridinetetraacetate was determined to be 18.6, a previously unreported value.
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页码：985 / 992
页数：8
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