CHEMISTRY OF O-SILYLATED KETENE ACETALS - A STEREOSELECTIVE SYNTHESIS OF OPTICALLY-ACTIVE CARBAPENEM ANTIBIOTICS, (+)-THIENAMYCIN AND (+)-PS-5

被引：0
作者：
KITA, Y
SHIBATA, N
MIKI, T
TAKEMURA, Y
TAMURA, O
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来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 01期
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中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A stereoselective synthesis of the chiral thienamycin intermediate (16) involving a diastereoselective Micheal addition and a silicon-induced Pummerer-type reaction is described. In a similar way, the key intermediate for (+)-PS-5 was also prepared from 4-(phenylsulfinylmethyl)butanamide (21).
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页码：12 / 20
页数：9
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