CHEMISTRY OF O-SILYLATED KETENE ACETALS - A STEREOSELECTIVE SYNTHESIS OF OPTICALLY-ACTIVE CARBAPENEM ANTIBIOTICS, (+)-THIENAMYCIN AND (+)-PS-5

被引：0

作者：

KITA, Y

SHIBATA, N

MIKI, T

TAKEMURA, Y

TAMURA, O

机构：

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 01期

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D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A stereoselective synthesis of the chiral thienamycin intermediate (16) involving a diastereoselective Micheal addition and a silicon-induced Pummerer-type reaction is described. In a similar way, the key intermediate for (+)-PS-5 was also prepared from 4-(phenylsulfinylmethyl)butanamide (21).

引用

页码：12 / 20

页数：9

共 32 条

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