Recent evidence indicates that in as diverse organisms as unicellular eukaryotes, higher plants and prokaryotes, anaerobic glycolysis relies on a pyrophosphate-dependent phosphofructokinase instead of the classical ATP-dependent enzyme. This difference in phosphoryl donor specificity does not necessarily reflect a primitive metabolism, as thought earlier, but could rather be the result of convergent evolution, fostered by the energetic advantage conferred to the cell when glycolysis is the sole source of ATP.
机构:Department of Biochemistry and Medicine, Case Western Reserve University, School of Medicine, Cleveland, OH 44106-4983, H.G. Wood Building, Room W137
PHILLIPS, NFB
LI, ZJ
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机构:Department of Biochemistry and Medicine, Case Western Reserve University, School of Medicine, Cleveland, OH 44106-4983, H.G. Wood Building, Room W137
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CASE WESTERN RESERVE UNIV,SCH MED,DEPT MED & BIOCHEM,DIV GEOG MED,CLEVELAND,OH 44106CASE WESTERN RESERVE UNIV,SCH MED,DEPT MED & BIOCHEM,DIV GEOG MED,CLEVELAND,OH 44106
LI, ZJ
PHILLIPS, NFB
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CASE WESTERN RESERVE UNIV,SCH MED,DEPT MED & BIOCHEM,DIV GEOG MED,CLEVELAND,OH 44106CASE WESTERN RESERVE UNIV,SCH MED,DEPT MED & BIOCHEM,DIV GEOG MED,CLEVELAND,OH 44106
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KTH Royal Inst Technol, Dept Ind Biotechnol, Sch Engn Sci Chem Biotechnol & Hlth, Stockholm, SwedenKTH Royal Inst Technol, Dept Ind Biotechnol, Sch Engn Sci Chem Biotechnol & Hlth, Stockholm, Sweden
Koendjbiharie, Jeroen G.
Kuil, Teun
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KTH Royal Inst Technol, Dept Ind Biotechnol, Sch Engn Sci Chem Biotechnol & Hlth, Stockholm, SwedenKTH Royal Inst Technol, Dept Ind Biotechnol, Sch Engn Sci Chem Biotechnol & Hlth, Stockholm, Sweden
Kuil, Teun
Nurminen, Carolus M. K.
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KTH Royal Inst Technol, Dept Ind Biotechnol, Sch Engn Sci Chem Biotechnol & Hlth, Stockholm, SwedenKTH Royal Inst Technol, Dept Ind Biotechnol, Sch Engn Sci Chem Biotechnol & Hlth, Stockholm, Sweden
Nurminen, Carolus M. K.
van Maris, Antonius J. A.
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KTH Royal Inst Technol, Dept Ind Biotechnol, Sch Engn Sci Chem Biotechnol & Hlth, Stockholm, SwedenKTH Royal Inst Technol, Dept Ind Biotechnol, Sch Engn Sci Chem Biotechnol & Hlth, Stockholm, Sweden