A MODEL FOR THE IDENTIFICATION OF HORMONE PULSES

被引：70

作者：

KUSHLER, RH

BROWN, MB

机构：

[1] Department of Mathematical Sciences, Oakland University, Rochester, Michigan

[2] Department of Biostatistics, University of Michigan, Ann Arbor, Michigan

来源：

STATISTICS IN MEDICINE | 1991年 / 10卷 / 03期

关键词：

D O I：

10.1002/sim.4780100305

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several hormones are released into the blood in a pulsating manner, that is, in short bursts which cause a rapid increase in the circulating concentration. The concentration then declines due to excretion, chemical breakdown, and redistribution into other compartments. Based on a series of observations of the level of hormone in the blood, investigators desire to quantify characteristics of these pulses, that is, timing, amplitude and rate of decay. We describe a statistical model for hormone pulse data and introduce a new method for estimating the characteristics of the pulses.

引用

页码：329 / 340

页数：12

共 22 条

[1]

Clifton D., Steiner R., Cycle detection: a technique for estimating the frequency and amplitude of episodic fluctuations in blood hormone and substrate concentrations, Endocrinology, 112, pp. 1057-1064, (1983)

[2]

Merriam G., Wachter K., Algorithms for the study of episodic hormone secretion, American Journal of Physiology, 243, (1982)

[3]

Van Cauter E., Quantitative methods for the analysis of circadian and episodic hormone fluctuations, Human Pituitary Hormones: Circadian and Episodic Variations, (1981)

[4]

Goodman R., Karsch F., Pulsatile secretion of luteinizing hormone: differential suppression by ovarian steroids, Endocrinology, 107, pp. 1286-1290, (1980)

[5]

Santen R., Bardin C., Episodic luteinizing hormone secretion in man: pulse analysis, clinical interpretation, physiologic mechanisms, Journal of Clinical Investigation, 52, pp. 2617-2628, (1973)

[6]

Oerter K., Guardabasso V., Rodbard D., Detection and characterization of peaks and estimation of instantaneous secretory rate for episodic pulsatile hormone secretion, Computers and Biomedical Research, 19, pp. 170-191, (1986)

[7]

Veldhuis J., Johnson M., Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection, Am J Physiol, 250, (1986)

[8]

Kushler R., (1987)

[9]

O'Sullivan F., O'Sullivan J., Deconvolution of episodic hormone data: an analysis of the role of season on the onset of puberty in cows, Biometrics, 44, pp. 339-353, (1988)

[10]

Diggle P., Zeger S., A non‐gaussian model for time series with pulses, Journal of the American Statistical Association, 84, pp. 354-359, (1989)

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