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EFFICACY OF AZITHROMYCIN IN THE TREATMENT OF GUINEA-PIGS INFECTED WITH LEGIONELLA-PNEUMOPHILA BY AEROSOL
被引:56
作者
:
FITZGEORGE, RB
论文数:
0
引用数:
0
h-index:
0
机构:
Public Health Laboratory Service, Centre for Applied Microbiology and Research, Salisbury, Wiltshire, SP4 0JG, Porton Down
FITZGEORGE, RB
FEATHERSTONE, ASR
论文数:
0
引用数:
0
h-index:
0
机构:
Public Health Laboratory Service, Centre for Applied Microbiology and Research, Salisbury, Wiltshire, SP4 0JG, Porton Down
FEATHERSTONE, ASR
BASKERVILLE, A
论文数:
0
引用数:
0
h-index:
0
机构:
Public Health Laboratory Service, Centre for Applied Microbiology and Research, Salisbury, Wiltshire, SP4 0JG, Porton Down
BASKERVILLE, A
机构
:
[1]
Public Health Laboratory Service, Centre for Applied Microbiology and Research, Salisbury, Wiltshire, SP4 0JG, Porton Down
来源
:
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
|
1990年
/ 25卷
关键词
:
D O I
:
10.1093/jac/25.suppl_A.101
中图分类号
:
R51 [传染病];
学科分类号
:
100401 ;
摘要
:
Azithromycin and erythromycin were compared for efficacy in guinea pigs infected with an aerosol containing Legionella pneumophila. When administered intraperitoneally, azithromycin was very effective in the treatment of experimental Legionnaires' disease. Even at the low dose of 3.6mg/kg/day it gave 100% survival and eliminated lung infectivity two days following infection. In contrast, erythromycin at a much higher dose (96 mg/kg/day) gave only 83.3% survival and failed to eliminate organisms from the lung six days after infection. The histological findings confirmed the superiority of azithromycin. A single dose of azithromycin given intraperitoneally at 3.6 or 14.4mg/kg gave survival rates of 83.3 and 100%, respectively. Azithromycin was also found to be superior to erythromycin in eliminating lung infectivity and reducing mortality, when administered orally. However, oral administration of azithromycin was not as effective as intraperitoneal when assessed by lung histopathology, although it was still superior to oral erythromycin treatment. © 1990 The British Society for Antimicrobial Chemotherapy.
引用
收藏
页码:101 / 108
页数:8
相关论文
共 13 条
[1]
BASKERVILLE A, 1981, LANCET, V2, P1389
[2]
FACTORS INFLUENCING THE ASSAY OF ANTIMICROBIAL DRUGS IN CLINICAL-SAMPLES BY THE AGAR PLATE DIFFUSION METHOD
[J].
DELOUVOIS, J
论文数:
0
引用数:
0
h-index:
0
DELOUVOIS, J
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
1982,
9
(04)
:253
-265
[3]
A MOBILE FORM OF HENDERSON APPARATUS
[J].
DRUETT, HA
论文数:
0
引用数:
0
h-index:
0
机构:
Microbiological Research Establishment, Salisbury
DRUETT, HA
.
JOURNAL OF HYGIENE-CAMBRIDGE,
1969,
67
(03)
:437
-+
[4]
IMPROVED SEMISELECTIVE MEDIUM FOR ISOLATION OF LEGIONELLA-PNEUMOPHILA FROM CONTAMINATED CLINICAL AND ENVIRONMENTAL SPECIMENS
[J].
EDELSTEIN, PH
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,RES & MED SERV,DIV INFECT DIS,LOS ANGELES,CA 90073
VET ADM WADSWORTH HOSP CTR,RES & MED SERV,DIV INFECT DIS,LOS ANGELES,CA 90073
EDELSTEIN, PH
.
JOURNAL OF CLINICAL MICROBIOLOGY,
1981,
14
(03)
:298
-303
[5]
THE EFFECT OF ANTIBIOTICS ON THE GROWTH OF LEGIONELLA-PNEUMOPHILA IN GUINEA-PIG ALVEOLAR PHAGOCYTES INFECTED INVIVO BY AN AEROSOL
[J].
FITZGEORGE, RB
论文数:
0
引用数:
0
h-index:
0
FITZGEORGE, RB
.
JOURNAL OF INFECTION,
1985,
10
(03)
:189
-193
[6]
THE PHARMACOKINETICS OF AZITHROMYCIN IN HUMAN SERUM AND TISSUES
[J].
FOULDS, G
论文数:
0
引用数:
0
h-index:
0
机构:
Drug Metabolism Department, Pfizer Central Research, Groton, CT
FOULDS, G
;
SHEPARD, RM
论文数:
0
引用数:
0
h-index:
0
机构:
Drug Metabolism Department, Pfizer Central Research, Groton, CT
SHEPARD, RM
;
JOHNSON, RB
论文数:
0
引用数:
0
h-index:
0
机构:
Drug Metabolism Department, Pfizer Central Research, Groton, CT
JOHNSON, RB
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
1990,
25
:73
-82
[7]
INVIVO SUSCEPTIBILITY OF LEGIONNAIRES DISEASE BACTERIUM TO 10 ANTI-MICROBIAL AGENTS
[J].
LEWIS, VJ
论文数:
0
引用数:
0
h-index:
0
LEWIS, VJ
;
THACKER, WL
论文数:
0
引用数:
0
h-index:
0
THACKER, WL
;
SHEPARD, CC
论文数:
0
引用数:
0
h-index:
0
SHEPARD, CC
;
MCDADE, JE
论文数:
0
引用数:
0
h-index:
0
MCDADE, JE
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
1978,
13
(03)
:419
-422
[8]
ERYTHROMYCIN IN LEGIONNAIRES-DISEASE - A RE-APPRAISAL
[J].
MILLER, AC
论文数:
0
引用数:
0
h-index:
0
MILLER, AC
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
1981,
7
(03)
:217
-222
[9]
RELATIONSHIP OF HIGH TISSUE CONCENTRATIONS OF AZITHROMYCIN TO BACTERICIDAL ACTIVITY AND EFFICACY INVIVO
[J].
RETSEMA, JA
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
RETSEMA, JA
;
GIRARD, AE
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
GIRARD, AE
;
GIRARD, D
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
GIRARD, D
;
MILISEN, WB
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
MILISEN, WB
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
1990,
25
:83
-89
[10]
PHARMACOKINETICS OF AZITHROMYCIN IN RATS AND DOGS
[J].
SHEPARD, RM
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
SHEPARD, RM
;
FALKNER, FC
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
FALKNER, FC
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
1990,
25
:49
-60
←
1
2
→
共 13 条
[1]
BASKERVILLE A, 1981, LANCET, V2, P1389
[2]
FACTORS INFLUENCING THE ASSAY OF ANTIMICROBIAL DRUGS IN CLINICAL-SAMPLES BY THE AGAR PLATE DIFFUSION METHOD
[J].
DELOUVOIS, J
论文数:
0
引用数:
0
h-index:
0
DELOUVOIS, J
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
1982,
9
(04)
:253
-265
[3]
A MOBILE FORM OF HENDERSON APPARATUS
[J].
DRUETT, HA
论文数:
0
引用数:
0
h-index:
0
机构:
Microbiological Research Establishment, Salisbury
DRUETT, HA
.
JOURNAL OF HYGIENE-CAMBRIDGE,
1969,
67
(03)
:437
-+
[4]
IMPROVED SEMISELECTIVE MEDIUM FOR ISOLATION OF LEGIONELLA-PNEUMOPHILA FROM CONTAMINATED CLINICAL AND ENVIRONMENTAL SPECIMENS
[J].
EDELSTEIN, PH
论文数:
0
引用数:
0
h-index:
0
机构:
VET ADM WADSWORTH HOSP CTR,RES & MED SERV,DIV INFECT DIS,LOS ANGELES,CA 90073
VET ADM WADSWORTH HOSP CTR,RES & MED SERV,DIV INFECT DIS,LOS ANGELES,CA 90073
EDELSTEIN, PH
.
JOURNAL OF CLINICAL MICROBIOLOGY,
1981,
14
(03)
:298
-303
[5]
THE EFFECT OF ANTIBIOTICS ON THE GROWTH OF LEGIONELLA-PNEUMOPHILA IN GUINEA-PIG ALVEOLAR PHAGOCYTES INFECTED INVIVO BY AN AEROSOL
[J].
FITZGEORGE, RB
论文数:
0
引用数:
0
h-index:
0
FITZGEORGE, RB
.
JOURNAL OF INFECTION,
1985,
10
(03)
:189
-193
[6]
THE PHARMACOKINETICS OF AZITHROMYCIN IN HUMAN SERUM AND TISSUES
[J].
FOULDS, G
论文数:
0
引用数:
0
h-index:
0
机构:
Drug Metabolism Department, Pfizer Central Research, Groton, CT
FOULDS, G
;
SHEPARD, RM
论文数:
0
引用数:
0
h-index:
0
机构:
Drug Metabolism Department, Pfizer Central Research, Groton, CT
SHEPARD, RM
;
JOHNSON, RB
论文数:
0
引用数:
0
h-index:
0
机构:
Drug Metabolism Department, Pfizer Central Research, Groton, CT
JOHNSON, RB
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
1990,
25
:73
-82
[7]
INVIVO SUSCEPTIBILITY OF LEGIONNAIRES DISEASE BACTERIUM TO 10 ANTI-MICROBIAL AGENTS
[J].
LEWIS, VJ
论文数:
0
引用数:
0
h-index:
0
LEWIS, VJ
;
THACKER, WL
论文数:
0
引用数:
0
h-index:
0
THACKER, WL
;
SHEPARD, CC
论文数:
0
引用数:
0
h-index:
0
SHEPARD, CC
;
MCDADE, JE
论文数:
0
引用数:
0
h-index:
0
MCDADE, JE
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
1978,
13
(03)
:419
-422
[8]
ERYTHROMYCIN IN LEGIONNAIRES-DISEASE - A RE-APPRAISAL
[J].
MILLER, AC
论文数:
0
引用数:
0
h-index:
0
MILLER, AC
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
1981,
7
(03)
:217
-222
[9]
RELATIONSHIP OF HIGH TISSUE CONCENTRATIONS OF AZITHROMYCIN TO BACTERICIDAL ACTIVITY AND EFFICACY INVIVO
[J].
RETSEMA, JA
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
RETSEMA, JA
;
GIRARD, AE
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
GIRARD, AE
;
GIRARD, D
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
GIRARD, D
;
MILISEN, WB
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
MILISEN, WB
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
1990,
25
:83
-89
[10]
PHARMACOKINETICS OF AZITHROMYCIN IN RATS AND DOGS
[J].
SHEPARD, RM
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
SHEPARD, RM
;
FALKNER, FC
论文数:
0
引用数:
0
h-index:
0
机构:
Central Research Division, Pfizer Inc., Groton, CT
FALKNER, FC
.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,
1990,
25
:49
-60
←
1
2
→