Solubility Study of Betulonic Acid in the Presence of Hydroxypropyl-gamma-cyclodextrin by Capillary Electrophoresis

被引：8

作者：

Popova, Olesya V. ^{[1
]}

Sursyakova, Viktoria V. ^{[1
]}

Burmakina, Galina V. ^{[1
,2
]}

Maksimov, Nikolay G. ^{[1
]}

Levdansky, Vladimir A. ^{[1
]}

Rubaylo, Anatoly I. ^{[1
,2
,3
]}

机构：

[1] FRC Krasnoyarsk Sci Ctr SB RAS, Inst Chem & Chem Technol SB RAS, 50-24 Akademgorodok, Krasnoyarsk 660036, Russia

[2] Siberian Fed Univ, 79 Svobodny, Krasnoyarsk 660041, Russia

[3] SB RAS, Krasnoyarsk Sci Ctr, 50 Akademgorodok, Krasnoyarsk 660036, Russia

来源：

JOURNAL OF SIBERIAN FEDERAL UNIVERSITY-CHEMISTRY | 2016年 / 9卷 / 02期

关键词：

capillary electrophoresis; betulonic acid; hydroxypropyl-gamma-cyclodextrin; inclusion complexes; solubility;

D O I：

10.17516/1998-2836-2016-9-2-171-176

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Solubility of betulonic acid in 40 mM hydroxypropyl-gamma-cyclodextrin solution was studied by capillary electrophoresis. It was shown that the equilibrium of complexation reaction between betulonic acid and hydroxypropyl-gamma-cyclodextrin was established for three days. The oxidation of betulonic acid by atmospheric oxygen was shown not to occur during the long stirring. The solubility of betulonic acid in 40 mM aqueous cyclodextrin solution was 410 +/- 20 mg/l.

引用

页码：171 / 176

页数：6

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