CONFORMATION, PARTITION, AND DRUG DESIGN

被引：14

作者：

DAVIES, RH

SHEARD, B

TAYLOR, PJ

机构：

[1] Pharmaceuticals Division Pharmaceuticals Div, Macclesfield, Cheshire, SK10 4TG, I.C.I. Alderley Park

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Conformations—drug; biological activity; fraction of conformer and partition coefficient; Partition coefficients—drug conformers; structure‐activity relationships; Structure‐activity relationships—drug conformers;

D O I：

10.1002/jps.2600680345

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：396 / 397

页数：2

共 16 条

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ABRAHAM, RJ ;

SIVERNS, TM .

TETRAHEDRON, 1972, 28 (11) :3015-&

[2]

ABRAHAM RJ, 1974, INTERNAL ROTATION MO

[3]

DAVIES RH, 1977, INT J QUANTUM CHEM, V4, P413

[4]

ELBERMANI MF, 1970, J AM CHEM SOC, V92, P6750

[5] CONFORMATION OF HISTAMINE DERIVATIVES .3. RELATIONSHIP BETWEEN CONFORMATION AND PHARMACOLOGICAL ACTIVITY [J].

GANELLIN, CR .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (06) :620-623

[6] RHO-SIGMA-PI ANALYSIS . METHOD FOR CORRELATION OF BIOLOGICAL ACTIVITY + CHEMICAL STRUCTURE [J].

HANSCH, C ;

FUJITA, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (08) :1616-&

[7]

Hansch C., 1971, DRUG DESIGN, V1

[8]

Kier L. B., 1971, MOL ORBITAL THEORY D

[9] PARTITION COEFFICIENTS AND THEIR USES [J].

LEO, A ;

HANSCH, C ;

ELKINS, D .

CHEMICAL REVIEWS, 1971, 71 (06) :525-+

[10]

MAUTNER HC, 1974, MOL QUANTUM PHARMACO

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