Comparison of Efficacy of Metformin Versus Pioglitazone in patients with Polycystic Ovarian Syndrome

被引：0

作者：

Razzaq, Moona ^{[1
]}

Wabasa, Nasma ^{[2
]}

Aslam, Hira ^{[3
]}

机构：

[1] THQ Hosp, Jampur, Pakistan

[2] Bahawal Victoria Hosp, Dept Accid & Emergency, Bahawalpur, Pakistan

[3] BVH, Dept Med, Bahawalpur, Pakistan

来源：

PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES | 2016年 / 10卷 / 04期

关键词：

Polycystic; ovaries; ovulation; metformin; pioglitazone;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: To compare the efficacy ofpioglitazone and metforminin women with polycystic ovary syndrome. Methods: This randomized trial was conducted at Department of Obstetrics & Gynecology, THQ Hospital Jampur from February 2016 to August 2016. Total 70 patients with polycystic ovary syndrome having 20-40 years of age with duration of disease > 3 month were recruited. Results: The mean age of women in group A was 29.97 +/- 5.28 years and in group B was 30.37 +/- 5.63 years. Mean duration of marriage in study group A was 4.74 +/- 2.40 years and in study group B was 4.91 +/- 2.25 years. The mean duration of disease in study group A was 3.69 +/- 1.59 years and in study group B was 3.94 +/- 1.84 years. Efficacy of Group A (metformin group) was 19 (54.29%) while in Group B (pioglitazone group) was 29 (82.86%) with p-value = 0.010. Conclusion: This studyconcluded that Pioglitazone is more effective as compare to metformin for ovulation induction in women with polycystic ovary syndrome.

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页码：1421 / 1424

页数：4

相关论文

共 19 条

[1]

Amer SA., 2009, OBSTET GYNAECOL REPR, V19, P263

[2] Metabolic and Hormonal Changes Induced by Pioglitazone in Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Clinical Trial [J].

Aroda, Vanita R. ;

Ciaraldi, Theodore P. ;

Burke, Paivi ;

Mudaliar, Sunder ;

Clopton, Paul ;

Phillips, Susan ;

Chang, R. Jeffrey ;

Henry, Robert R. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (02) :469-476

[3] Treatment options for polycystic ovary syndrome [J].

Badawy, Ahmed ;

Elnashar, Abubaker .

INTERNATIONAL JOURNAL OF WOMENS HEALTH, 2011, 3 :25-35

[4] Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome [J].

Begum, Mosammat Rashida ;

Ferdous, Jannatul ;

Begum, Anowara ;

Quadir, Ehsan .

FERTILITY AND STERILITY, 2009, 92 (03) :853-857

[5] Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome [J].

Brettenthaler, N ;

De Geyter, C ;

Huber, PR ;

Keller, U .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (08) :3835-3840

[6] Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: A randomized, double-blind, and placebo control trial [J].

Fux Otta, Carolina ;

Wior, Myriam ;

Iraci, Gabriel S. ;

Kaplan, Raquel ;

Torres, Diana ;

Isabel Gaido, Maria ;

Wyse, Eduardo P. .

GYNECOLOGICAL ENDOCRINOLOGY, 2010, 26 (03) :173-178

[7] Pioglitazone and metformin in obese women with polycystic ovary syndrome not optimally responsive to metformin [J].

Glueck, CJ ;

Moreira, A ;

Goldenberg, N ;

Sieve, L ;

Wang, P .

HUMAN REPRODUCTION, 2003, 18 (08) :1618-1625

[8] Comparison of endocrine and ultrasound profiles during ovulation induction with clomiphene citrate and letrozole in ovulatory volunteer women [J].

Jirge, Padma Rekha ;

Patil, Rajendra S. .

FERTILITY AND STERILITY, 2010, 93 (01) :174-183

[9] Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome - A meta-analysis of randomised trials [J].

Johnson, Neil .

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 2011, 51 (02) :125-129

[10] Metformin vs thiazolidinediones for treatment of clinical, hormonal and metabolic characteristics of polycystic ovary syndrome: a meta-analysis [J].

Li, X-J ;

Yu, Y-X ;

Liu, C-Q ;

Zhang, W. ;

Zhang, H-J ;

Yan, B. ;

Wang, L-Y ;

Yang, S-Y ;

Zhang, S-H .

CLINICAL ENDOCRINOLOGY, 2011, 74 (03) :332-339