RESPONSE OF GROWING BONE TO IRRADIATION - A PROPOSED LATE EFFECTS SCORING SYSTEM

被引：80

作者：

EIFEL, PJ

DONALDSON, SS

THOMAS, PRM

机构：

[1] STANFORD UNIV HOSP,DEPT RADIAT ONCOL,STANFORD,CA 94305

[2] TEMPLE UNIV,CTR COMPREHENS CANC,PHILADELPHIA,PA 19122

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1995年 / 31卷 / 05期

关键词：

RADIATION THERAPY; NORMAL TISSUE TOXICITY; GROWING BONE;

D O I：

10.1016/0360-3016(94)00420-P

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of radiation on epiphyseal bone growth is one of the most important dose-limiting factors in the radiotherapeutic management of children with malignant neoplasms. Clinical and laboratory evidence suggest that many factors may influence the severity of radiation-induced growth arrest. However, the absence of a consistent scoring system for late effects has hampered efforts to analyze the influence of various therapeutic maneuvers or to compare and collate results from different reported series, In this review, laboratory and clinical studies of radiation effects on growing bone are summarized, and a late effects scoring system is proposed.

引用

页码：1301 / 1307

页数：7

共 35 条

[1] GROWTH AND PREDICTIONS OF GROWTH IN THE LOWER EXTREMITIES [J].

ANDERSON, M ;

GREEN, WT ;

MESSNER, MB .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1963, 45 (01) :1-14

[2]

COWELL B, 1966, CLIN ORTHOPAEDICS, V48, P89

[3]

DICKERMAN JD, 1979, CANCER, V44, P480, DOI 10.1002/1097-0142(197908)44:2<480::AID-CNCR2820440216>3.0.CO

[4]

2-A

[5] RADIATION FRACTIONATION SENSITIVITY OF EPIPHYSEAL CARTILAGE IN A WEANLING RAT MODEL [J].

EIFEL, PJ ;

SAMPSON, CM ;

TUCKER, SL .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1990, 19 (03) :661-664

[6]

EIFEL PJ, 1991, RAD RES 20TH CENTURY, V1, P162

[7] EXPERIMENTAL STUDIES ON THE RESPONSE OF GROWING BONES TO X-RAY AND NEUTRON-IRRADIATION [J].

GONZALEZ, DG ;

VANDIJK, JDP .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1983, 9 (05) :671-677

[8] CLINICAL-DATA FROM IRRADIATED GROWING LONG BONES IN CHILDREN [J].

GONZALEZ, DG ;

BREUR, K .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1983, 9 (06) :841-846

[9] SKELETAL EFFECTS OF MEGAVOLTAGE IRRADIATION IN SURVIVORS OF WILMS TUMOR [J].

HEASTON, DK ;

LIBSHITZ, HI ;

CHAN, RC .

AMERICAN JOURNAL OF ROENTGENOLOGY, 1979, 133 (03) :389-395

[10]

Hinkel CL, 1943, AM J ROENTGENOL RADI, V49, P321

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