4H-PYRROLO[1,2-A]THIENO[3,2-F] AND 4H-PYRROLO[1,2-A]THIENO[2,3-F][1,4]DIAZEPINES - SYNTHESIS AND PHARMACOLOGICAL EVALUATION

被引:5
|
作者
VEGA, S [1 ]
GIL, MS [1 ]
DARIAS, V [1 ]
MATEO, CCS [1 ]
EXPOSITO, MA [1 ]
TELLO, ML [1 ]
ALBERTOS, LM [1 ]
机构
[1] UNIV LA LAGUNA,FAC FARM,DEPT FARMACOL,TENERIFE,SPAIN
关键词
D O I
10.1002/ardp.19943271108
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
As an extension of a previous work, in which a number of 4H-pyrrolo-[1,2-a]thieno[2,3-f][1,4]diazepines were described a new series of derivatives of the isomeric pyrrolo[1,2-a]thieno[3,2-f]diazepines ring system has been synthesized. The products obtained, together with those reported in the previous paper, were rested for acute toxicity and CNS activity in mice.
引用
收藏
页码:721 / 728
页数:8
相关论文
共 50 条
  • [11] Synthesis of a new pyrrolo[1,3]diazepine: 4H-pyrrolo[1,2-a]thieno[2,3-e][1,3]diazepine
    Daich, A
    Ohier, P
    Decroix, B
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 32 (06) : 1731 - 1734
  • [12] INTRAMOLECULAR CYCLIZATION - SYNTHESIS OF 9-OXO-4H,9H-PYRROLO[1,2-A]THIENO[2,3-D]PYRIDINE AND 4-OXO-4H,9H-PYRROLO[1,2-A]THIENO[2,3-D]PYRIDINE - SYNTHESIS OF PYRROLO[1,2-A]THIENO[3,2-E][1,4]DIAZEPINE AND PYRROLO[1,2-A]THIENO[2,3-E][1,4]DIAZEPINE
    DECROIX, B
    MOREL, J
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (01) : 81 - 87
  • [13] Desulfurization of pyrido[3′,2′:4,5]thieno-[2,3-f]pyrrolo[1,2-a][1,4]diazepines
    V. M. Red’kin
    T. A. Stroganova
    V. K. Vasilin
    G. D. Krapivin
    Chemistry of Heterocyclic Compounds, 2012, 47 : 1319 - 1320
  • [14] DESULFURIZATION OF PYRIDO[3′,2′:4,5]THIENO-[2,3-f]PYRROLO[1,2-a][1,4]DIAZEPINES
    Red'kin, V. M.
    Stroganova, T. A.
    Vasilin, V. K.
    Krapivin, G. D.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2012, 47 (10) : 1319 - 1320
  • [15] SIMPLE SYNTHESES OF PYRIDO[1,2-A]BENZIMIDAZOLES AND OF 4H-PYRROLO[1,2-A]BENZIMIDAZOLES
    GALONS, H
    COMBETFARNOUX, C
    MIOCQUE, M
    PHARMAZIE, 1987, 42 (08): : 548 - 549
  • [16] SYNTHESIS AND STUDY OF 4 H-5,6-DIHYDRO PYRROLO [1,2-A]THIENO[3,2-F]1,4-DIAZEPINE
    RAULT, S
    CUGNONDESEVRICOURT, M
    ROBBA, M
    COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE C, 1978, 287 (04): : 117 - 120
  • [17] SYNTHESIS AND PHARMACOLOGICAL STUDY OF 5,6,8,9-TETRAHYDRO-4H,7H-PYRROLO[ 1,2-A]CYCLOPENTA[B]THIENO[3,2-F][1,4]DIAZEPINES
    VEGA, S
    GIL, MS
    DARIAS, V
    MATEO, CCS
    EXPOSITO, MA
    PHARMAZIE, 1995, 50 (01): : 27 - 33
  • [18] First synthesis of 5,6-dihydro-4H-furo[3,2-f]pyrrolo[1,2-a][1,4]diazepines
    Feng, X
    Lancelot, JC
    Gillard, AC
    Landelle, H
    Rault, S
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1998, 35 (06) : 1313 - 1316
  • [19] PYRROLO [1,2-A] THIENO [3,2-F] 1,4-DIAZEPINES - NOVEL SYNTHESIS AND X-RAY ANALYSIS
    RAULT, S
    CUGNONDESEVRICOURT, M
    ROBBA, M
    DUNG, NH
    TETRAHEDRON LETTERS, 1979, (07) : 643 - 644
  • [20] A NOVEL PRACTICAL SYNTHESIS OF PYRROLO[1,2-A]THIENO[2,3-E][1,4]DIAZEPINES
    DAICH, A
    MOREL, J
    DECROIX, B
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1993, 30 (03) : 675 - 678