A DIAZINE HETEROCYCLE REPLACES A 6-MEMBERED HYDROGEN-BONDED ARRAY IN THE ACTIVE-SITE OF SCYTALONE DEHYDRATASE

被引：43

作者：

HODGE, CN ^{[1
]}

PIERCE, J ^{[1
]}

机构：

[1] DUPONT CO INC,DEPT AGR PROD,WILMINGTON,DE 19880

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80026-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4-aminoquinazoline II is a fully functional substitute for salicylamide I as a competitive inhibitor of scytalone dehydratase. Kinetic measurements demonstrate that both inhibitors bind to the enzyme in their neutral form, suggesting that the hydrogen-bonded array in I binds to the enzyme active site as an intact structural element.

引用

页码：1605 / 1608

页数：4

共 14 条

[1]

BECKET GJP, 1978, J CHEM RES-S, P47

[2] EFFECT OF INHIBITORS OF MELANIN BIOSYNTHESIS ON APPRESSORIAL PENETRATION AND REDUCTIVE REACTIONS IN PYRICULARIA-ORYZAE AND PYRICULARIA-GRISEA [J].