ANTIINFLAMMATORY ACTIVITY OF LANNEA-COROMANDELICA BARK EXTRACT IN RATS

被引：14
作者：
SINGH, S
SINGH, GB
机构：
[1] Department of Pharmacology, Regional Research Laboratory, Jammu‐Tawi
来源：
PHYTOTHERAPY RESEARCH | 1994年 / 8卷 / 05期
关键词：
LANNEA COROMANDELICA; ANTIINFLAMMATORY ACTIVITY; CARRAGEENAN EDEMA; ADJUVANT ARTHRITIS;
D O I：
10.1002/ptr.2650080513
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Oral administration of an ethanolic extract of Lannea coromandelica (ELC) demonstrated a dose related antiinflammatory activity (AIA) in carrageenan and dextran induced oedema and adjuvant induced arthritis in rats. ELC reduced the pleural exudate volume and inhibited leucocyte migration in carrageenan-induced pleurisy in rats. It lacked analgesic, antipyretic or ulcerogenic effect and failed to exhibit any effect in cotton pellet granuloma. It did not prolong the gestation period, parturition time in pregnant rats or the onset time of diarrhoea in rats induced by castor oil. The ALD(50) is greater than 2 g/kg p.o. in mice.
引用
收藏
页码：311 / 313
页数：3
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