ANTINEOPLASTIC AND ANTIVIRAL ACTIVITIES OF PODOPHYLLOTOXIN RELATED LIGNANS

被引：53
|
作者：
GORDALIZA, M [1 ]
CASTRO, MA [1 ]
GARCIAGRAVALOS, MD [1 ]
RUIZ, P [1 ]
DELCORRAL, JMM [1 ]
SANFELICIANO, A [1 ]
机构：
[1] PHARMAMAR SA, E-28070 MADRID, SPAIN
来源：
ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 03期
关键词：
D O I：
10.1002/ardp.19943270309
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lung carcinoma, and HT-29 colon carcinoma, while antiviral assays were performed on herpes simplex virus type I infecting fibroblasts of monkey kidney (HSV/CV-1) and on vesicular stomatitis virus infecting fibroblasts of hamster kidney (VSV/BHK). A number of substances were active in both groups of assays at concentrations below 1 mu M; deoxypodophyllotoxin (1) being the most potent compound in all cases.
引用
收藏
页码：175 / 179
页数：5
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