EXCIPIENT ABILITY OF CHITOSAN FOR DIRECT TABLETTING

This paper describes an investigation of the usefulness of krill chitosan in the production of tablets that meet the standard requirements following long-term storage; 49% (A) and 66% (B) deacetylated chitosans were used. Examination of the granulometric and flow properties of multi-component mixtures containing B and testing of the direct compressibility of chitosan B and B mixtures showed that chitosan fulfills the general requirements for auxiliary substances in the process of direct tableting. When used as a filler or binder, chitosan did not affect mass flow; however, on addition in the proportion of 50% of tablet mass, rapid tablet disintegration resulted. Following long-term storage, tablets produced with the addition of B may be less resistant mechanically (tablet hardness decreases), nevertheless, the tablet disintegration time either remains unaffected or even decreases.