PREPARATION OF AN ANGIOTENSIN-I ANALOG CONTAINING A PARA-PHOSPHONOMETHYL-L-PHENYLALANINE RESIDUE VIA ASYMMETRIC-SYNTHESIS OF TERT-BOC-PARA-DIMETHYLPHOSPHONOMETHYL-L-PHENYLALANINE

被引：36

作者：

CUSHMAN, M

LEE, ES

机构：

[1] Department of Medicinal Chemistry, Pharmacognosy Purdue University, West Lafayette

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 09期

关键词：

PARA-PHOSPHONOMETHYL-L-PHENYLALANINE; PROTEIN-TYROSINE KINASE; TERT-BOC-PARA-DIMETHYLPHOSPHONOMETHYL-L-PHENYLALANINE; PHOSPHOTYROSINE; PROTEIN-TYROSINE PHOSPHATASE;

D O I：

10.1016/S0040-4039(00)91893-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

t-BOC-p-Dimethylphosphonomethyl-L-phenylalanine has been prepared and incorporated into a peptide sequence corresponding to angiotensin I. Demethylation of the dimethylphosphonomethyl moiety then yielded a peptide containing a p-phosphonomethyl-L-phenylalanine residue.

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页码：1193 / 1196

页数：4

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