PREPARATION OF AN ANGIOTENSIN-I ANALOG CONTAINING A PARA-PHOSPHONOMETHYL-L-PHENYLALANINE RESIDUE VIA ASYMMETRIC-SYNTHESIS OF TERT-BOC-PARA-DIMETHYLPHOSPHONOMETHYL-L-PHENYLALANINE

被引：36
作者：
CUSHMAN, M
LEE, ES
机构：
[1] Department of Medicinal Chemistry, Pharmacognosy Purdue University, West Lafayette
来源：
TETRAHEDRON LETTERS | 1992年 / 33卷 / 09期
关键词：
PARA-PHOSPHONOMETHYL-L-PHENYLALANINE; PROTEIN-TYROSINE KINASE; TERT-BOC-PARA-DIMETHYLPHOSPHONOMETHYL-L-PHENYLALANINE; PHOSPHOTYROSINE; PROTEIN-TYROSINE PHOSPHATASE;
D O I：
10.1016/S0040-4039(00)91893-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
t-BOC-p-Dimethylphosphonomethyl-L-phenylalanine has been prepared and incorporated into a peptide sequence corresponding to angiotensin I. Demethylation of the dimethylphosphonomethyl moiety then yielded a peptide containing a p-phosphonomethyl-L-phenylalanine residue.
引用
收藏
页码：1193 / 1196
页数：4
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