EFFECTS OF TAXOTERE ON MURINE AND HUMAN TUMOR-CELL LINES

被引:140
|
作者
RIOU, JF
NAUDIN, A
LAVELLE, F
机构
[1] Rhône-Poulenc Rorer, Unité de Cancérologie, Centre de Recherche de Vitry-Alfortville
关键词
D O I
10.1016/S0006-291X(05)81474-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Taxotere (RP 56976, NSC 628503), an analog of taxol, is an inhibitor of depolymerisation of microtubules and is currently in Phase I clinical trials. Comparisons of the cytotoxicities of Taxotere and taxol have been studied on several murine (P388, SVras) and human cell lines (Calc18, HCT116, T24, N417, KB). Taxotere was found more potent than taxol (1.3-12 fold), a result which could be explained by its higher affinity than taxol for microtubules. In agreement with its postulated mechanism of action, Taxotere is more cytotoxic on proliferating than on non proliferating N417 cells and does not inhibit cellular DNA, RNA and protein synthesis. Taxotere gives partial cross resistance on P-glycoprotein resistant P388/DOX cell line, in contrast to taxol which gives a complete cross resistance. On the other hand, no cross resistances were observed on Calc18/AM and P388/CPT5 cell lines, bearing modified activities of topoisomerase II and topoisomerase I, respectively. These results underline the higher cytotoxic activity of Taxotere compared to taxol, and the lack of cross resistance of that class of agent with the topoisomerase I and II-related multidrug resistance phenotypes. © 1992 Academic Press, Inc.
引用
收藏
页码:164 / 170
页数:7
相关论文
共 50 条
  • [41] HUMAN NORMAL AND TUMOR-CELL LINES - COMPARISON OF FIBRONECTINS AND COLLAGENS
    ALI, IU
    RASHEED, S
    CANCER INVESTIGATION, 1987, 5 (01) : 17 - 24
  • [42] DISTINCTIVE BANDED MARKER CHROMOSOMES OF HUMAN TUMOR-CELL LINES
    NELSONREES, WA
    FLANDERMEYER, RR
    HAWTHORNE, PK
    INTERNATIONAL JOURNAL OF CANCER, 1975, 16 (01) : 74 - 82
  • [43] NEUTRAL SURFACE AMINOPEPTIDASE ACTIVITY OF HUMAN TUMOR-CELL LINES
    AMOSCATO, AA
    SRAMKOSKI, RM
    BABCOCK, GF
    ALEXANDER, JW
    BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1041 (03) : 317 - 319
  • [44] CHARACTERIZATION OF 3 ESTABLISHED HUMAN TESTIS TUMOR-CELL LINES
    CASPER, J
    SCHMOLL, HJ
    SCHNAIDT, U
    FONATSCH, C
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1983, 105 (02) : A5 - A5
  • [45] HUMAN BREAST TUMOR-CELL LINES - IDENTITY EVALUATION BY ULTRASTRUCTURE
    BUEHRING, GC
    HACKETT, AJ
    JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1974, 53 (03) : 621 - 629
  • [46] STABILITY OF ISOENZYME PHENOTYPES TO IDENTIFY HUMAN TUMOR-CELL LINES
    WRIGHT, WC
    FOGH, J
    IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION, 1978, 14 (04): : 369 - 369
  • [47] ANIMAL-MODEL FOR GROWTH OF HUMAN TUMOR-CELL LINES
    OLDROYD, RI
    POOLE, RR
    REED, RR
    LAWSON, RK
    HODGES, CV
    INVESTIGATIVE UROLOGY, 1977, 14 (06): : 434 - 439
  • [48] DEFEROXAMINE AND HUMAN NEUROBLASTOMA AND PRIMITIVE NEUROECTODERMAL TUMOR-CELL LINES
    HELSON, C
    HELSON, L
    ANTICANCER RESEARCH, 1992, 12 (02) : 481 - 483
  • [49] IODODEOXYURIDINE INCORPORATION AND RADIOSENSITIZATION IN 3 HUMAN TUMOR-CELL LINES
    UHL, V
    PHILLIPS, TL
    ROSS, GY
    BODELL, WJ
    RASMUSSEN, J
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1992, 22 (03): : 489 - 494
  • [50] TUMOR-NECROSIS-FACTOR PRODUCTION IN HUMAN EPITHELIAL TUMOR-CELL LINES
    SPRIGGS, DR
    IMAMURA, K
    RODRIGUEZ, C
    SARIBAN, E
    HORIGUCHI, J
    SHERMAN, ML
    KUFE, DW
    IMMUNOBIOLOGY, 1987, 175 (1-2) : 35 - 36