MODULATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR TYROSINE PHOSPHORYLATION BY TUMOR-NECROSIS-FACTOR

被引：4

作者：

GUAZZONI, L ^{[1
]}

PEREGO, P ^{[1
]}

BANFI, P ^{[1
]}

ZUNINO, F ^{[1
]}

机构：

[1] IST NAZL STUDIO & CURA TUMORI,DIV EXPTL ONCOL B,VIA VENEZIAN 1,I-20133 MILAN,ITALY

来源：

CANCER LETTERS | 1991年 / 57卷 / 02期

关键词：

EPIDERMAL GROWTH FACTOR; TUMOR NECROSIS FACTOR;

D O I：

10.1016/0304-3835(91)90202-S

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of tumor necrosis factor (TNF) on epidermal growth factor (EGF) receptor tyrosine phosphorylation were investigated in Swiss 3T3 cells, which are sensitive to TNF action. At cytotoxic levels, TNF produced an appreciable inhibition of EGF-induced autophosphorylation of the receptor. A similar inhibition was detected even after prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) which produces down-regulation of protein kinase C (PKC). According to this finding, TNF does not induce phosphorylation of the 80 kDa PKC-specific substrate. These results support the hypothesis that the inhibition of EGF receptor tyrosine phosphorylation is not mediated via stimulation of PKC activity in intact Swiss 3T3 cells.

引用

页码：103 / 108

页数：6

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