HOMOCYSTEINE AS A RISK FACTOR FOR CARDIOVASCULAR-DISEASE

被引：9
作者：
GRAHAM, IM
机构：
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 1991年 / 1卷 / 06期
关键词：
D O I：
10.1016/1050-1738(91)90029-E
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Homocysteine is an amino acid that appears to damage the vascular endothelium and promote thrombosis. The most frequent causes of hyperhomocyst(e)inemia are the inherited defect of the enzyme cystathinonine B-synthase and nutritional deficiency of vitamin B-12 or folate. Hyperhomocyst(e)inemia is associated, perhaps causally, with atherosclerotic vascular disease. Interactions with risk factors such as cigarette smoking, hyperlipidemia, and hypertension are possible, but not yet defined. Dietary supplementation with vitamin B-12, folate, and other substances can reduce homocysteine levels. Such simple measures may reduce the risk of vascular disease in hyperhomocyst(e)inemic subjects.
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页码：244 / 249
页数：6
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