APPLICATION OF LECTIN HISTOCHEMISTRY AND CARBOHYDRATE ANALYSIS TO THE CHARACTERIZATION OF LYSOSOMAL STORAGE DISEASES

被引：23
作者：
ALROY, J
DEGASPERI, R
WARREN, CD
机构：
[1] TUFTS UNIV,SCH MED,SCH VET MED,BOSTON,MA 02111
[2] HARVARD UNIV,MASSACHUSETTS GEN HOSP,CARBOHYDRATE RES LAB,BOSTON,MA 02114
[3] HARVARD UNIV,SCH MED,DEPT BIOL CHEM,BOSTON,MA 02115
[4] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115
来源：
CARBOHYDRATE RESEARCH | 1991年 / 213卷
关键词：
D O I：
10.1016/S0008-6215(00)90611-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In lysosomal storage diseases that involve a defect in the catabolism of glycoconjugates, lectin histochemistry adds a new dimension to the characterization of stored carbohydrates as it identifies sugar residues in situ in the affected cells and, thus, determines which cell types are affected by storage. It may be combined with chemical and biochemical analysis by h.p.l.c. The present review summarizes recent results for a variety of storage diseases and presents new data for G(M1)-gangliosidosis.
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页码：229 / 250
页数：22
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