3,5-DIPHENYL-1H-PYRAZOLE DERIVATIVES .8. N-SUBSTITUTED 3-(4-HYDROXY-3,5-DIPHENYL-1H-PYRAZOL-1-YL)PROPANAMIDES, N-SUBSTITUTED 3-(4-HYDROXY-3,5-DIPHENYL-1H-PYRAZOL-1-YL)PROPANAMINES AND 2-(4-HYDROXY-3,5-DIPHENYL-1H-PYRAZOL-1-YL)ETHANAMINES WITH PLATELET ANTIAGGREGATING, HYPOTENSIVE, ANTIARRHYTHMIC AND OTHER ACTIVITIES

The synthesis of N,N-disubstituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides and -propanamines, starting from 4-benzoyloxy-3,5-diphenyl-1H-pyrazole, and of N-substituted 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines, starting from 4-acetoxy-1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole, is described. Some of the above compounds showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as moderate hypotensive, antiarrhythmic, local anesthetic, sedative and antiinflammatory activities in rats and mice.