3,5-DIPHENYL-1H-PYRAZOLE DERIVATIVES .8. N-SUBSTITUTED 3-(4-HYDROXY-3,5-DIPHENYL-1H-PYRAZOL-1-YL)PROPANAMIDES, N-SUBSTITUTED 3-(4-HYDROXY-3,5-DIPHENYL-1H-PYRAZOL-1-YL)PROPANAMINES AND 2-(4-HYDROXY-3,5-DIPHENYL-1H-PYRAZOL-1-YL)ETHANAMINES WITH PLATELET ANTIAGGREGATING, HYPOTENSIVE, ANTIARRHYTHMIC AND OTHER ACTIVITIES

被引：0
|
作者：
BRUNO, O
BONDAVALLI, F
RANISE, A
SCHENONE, P
CENICOLA, ML
DONNOLI, D
FILIPPELLI, W
LOSASSO, C
COSTANTINO, M
MARMO, E
机构：
[1] UNIV GENOA,IST SCI FARMACEUT,VIALE BENEDETTO XV 3,I-16132 GENOA,ITALY
[2] UNIV FEDERICO II,FAC MED & CHIRURG,IST FARMACOL & TOSSICOL,I-80138 NAPLES,ITALY
来源：
FARMACO | 1991年 / 46卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The synthesis of N,N-disubstituted 3-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)-propanamides and -propanamines, starting from 4-benzoyloxy-3,5-diphenyl-1H-pyrazole, and of N-substituted 2-(4-hydroxy-3,5-diphenyl-1H-pyrazol-1-yl)ethanamines, starting from 4-acetoxy-1-(2-hydroxyethyl)-3,5-diphenyl-1H-pyrazole, is described. Some of the above compounds showed a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as moderate hypotensive, antiarrhythmic, local anesthetic, sedative and antiinflammatory activities in rats and mice.
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页码：477 / 499
页数：23
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