CHARACTERIZATION OF HUMAN AUTOANTIBODIES SPECIFIC FOR LAMIN-A

被引：16

作者：

COURVALIN, JC ^{[1
]}

CHAUDHARY, N ^{[1
]}

DANON, F ^{[1
]}

BROUET, JC ^{[1
]}

LASSOUED, K ^{[1
]}

机构：

[1] INSERM, U108, IMMUNOCHEM & IMMUNOPATHOL LAB, F-75005 PARIS, FRANCE

来源：

BIOLOGY OF THE CELL | 1990年 / 69卷 / 02期

关键词：

autoantibodies; lamin A; nuclear envelope;

D O I：

10.1016/0248-4900(90)90334-Y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have characterized human autoimmune polyclonal antibodies reactive with lamin A, a 74 kDa peripheral protein of the nuclear envelope. Unlike other known antibodies to lamin A, the antibodies described here do not crossreact with the structurally related lamin C. These antibodies feature only x light chains suggesting that their specificity is restricted to a limited number of epitopes. Based on the known amino acid sequence of human lamins A and C, the epitope(s) are most likely located in the 80 amino acid carboxyl tail of mature lamin A. © 1990.

引用

页码：93 / 97

页数：5

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