PRESENTATION OF VIRAL-ANTIGEN CONTROLLED BY A GENE IN THE MAJOR HISTOCOMPATIBILITY COMPLEX

被引：406

作者：

CERUNDOLO, V ^{[1
]}

ALEXANDER, J ^{[1
]}

ANDERSON, K ^{[1
]}

LAMB, C ^{[1
]}

CRESSWELL, P ^{[1
]}

MCMICHAEL, A ^{[1
]}

GOTCH, F ^{[1
]}

TOWNSEND, A ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT MICROBIOL & IMMUNOL,DURHAM,NC 27710

来源：

NATURE | 1990年 / 345卷 / 6274期

关键词：

D O I：

10.1038/345449a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

WE describe a mutant human cell line (LBL 721.174)1,2 that has lost a function required for presentation of intracellular viral antigens with class I molecules of the major histocompatibility complex (MHC), but retains the capacity to present defined epitopes as extracellular peptides. The cell also has a defect in the assembly and expression of class I MHC molecules2,3,4, which we show can be restored by exposure of the cells to a peptide epitope. This phenotype suggests a defect in the association of intracellular antigen with class I molecules similar to that described for the murine mutant RMA-S (ref. 5), but in the present case the genetic defect can be mapped within the MHC locus on human chromosome 6. © 1990 Nature Publishing Group.

引用

页码：449 / 452

页数：4

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