1ST TRIMESTER MATERNAL SERUM ALPHA-FETOPROTEIN SCREENING FOR DOWN-SYNDROME AND OTHER ANEUPLOIDIES

被引：0

作者：

WENGER, D ^{[1
]}

MINY, P ^{[1
]}

HOLZGREVE, W ^{[1
]}

FUHRMANN, W ^{[1
]}

ALTLAND, K ^{[1
]}

机构：

[1] UNIV GIESSEN,ZENTRUM FRAUENHEILKUNDE,W-6300 GIESSEN,GERMANY

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1990年

关键词：

AFP; PREGNANCY; CHORIONIC VILLUS SAMPLING;

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Low maternal serum AFP (MSAFP) values in the first trimester of pregnancy have been associated with an increased risk for chromosome disorders. In our own first trimester chorionic villus sampling (CVS) series, MSAFP determinations were carried out in 1,448 singleton pregnancies. Aneuploidies were detected in 26 of these. The pre-CVS MSAFP values in these pregnancies were compared to those in pregnancies with normal outcome. Statistical analysis did not show a diagnostically useful correlation between low first trimester MSAFP values and aneuploidy in our cohort.

引用

页码：89 / 90

页数：2

共 7 条

[1] BARKAI G, 1987, LANCET, V2, P389
[2] BRAMBATI B, 1986, LANCET, V2, P165
[3] CUCKLE HS, 1984, LANCET, V1, P926
[4] FETOMATERNAL TRANSFUSION AFTER CHORIONIC VILLUS SAMPLING - EVALUATION BY MATERNAL SERUM ALPHAFETOPROTEIN MEASUREMENT
FUHRMANN, W
ALTLAND, K
KOHLER, A
HOLZGREVE, W
JOVANOVIC, V
RAUSKOLB, R
PAWLOWITZKI, IH
MINY, P
[J]. HUMAN GENETICS, 1988, 78 (01) : 83 - 85
[5] FUHRMANN W, 1984, LANCET, V1, P413
[6] AN ASSOCIATION BETWEEN LOW MATERNAL SERUM ALPHA-FETOPROTEIN AND FETAL CHROMOSOMAL-ABNORMALITIES
MERKATZ, IR
NITOWSKY, HM
MACRI, JN
JOHNSON, WE
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1984, 148 (07) : 886 - 894
[7] 1ST-TRIMESTER MATERNAL SERUM ALPHA-FETOPROTEIN SCREENING FOR CHROMOSOME DEFECTS
MILUNSKY, A
WANDS, J
BRAMBATI, B
BONACCHI, I
CURRIE, K
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1988, 159 (05) : 1209 - 1213

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