MASS-SPECTROMETRIC INVESTIGATION OF 2-AMINOPROPIOPHENONES AND SOME OF THEIR METABOLITES

被引：16
|
作者：
POKRAJAC, M [1 ]
MILJKOVIC, B [1 ]
MISAILOVIC, B [1 ]
机构：
[1] UNIV BELGRADE, FAC PHARM, DEPT PHARMACOL & PHARMACOKINET, YU-11000 BELGRADE, YUGOSLAVIA
来源：
RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1991年 / 5卷 / 02期
关键词：
D O I：
10.1002/rcm.1290050202
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Complex metabolic mixtures of 2-aminopropiophenones, obtained both after in vitro and human in vivo metabolism of these compounds, have been investigated using both mass spectrometry and gas chromatography/mass spectrometry. The mass spectrometric fragmentation schemes of the compounds have been proposed and verified. The schemes are based on the characteristic fragments obtained by alpha-cleavage of these compounds using direct inlet mass spectrometry or gas chromatography/mass spectrometry. These findings were confirmed with chemical ionization mass spectrometry, when quasi-molecular (MH+) ions were obtained as the highest relative abundance ions for all the compounds investigated, and were used in metabolic investigations of 2-aminopropiophenones.
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页码：59 / 61
页数：3
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