EFFECTS OF MORPHINE ON PLASMA B-ENDORPHIN AND CORTISOL-LEVELS AND ON BODY-TEMPERATURE IN GUINEA-PIGS PRETREATED WITH 6-HYDROXYDOPAMINE

被引：2

作者：

MILANES, MV

DELRIOGARCIA, J

CREMADES, A

FUENTE, T

机构：

[1] UNIV MURCIA, SCH MED, DEPT PHYSIOL & PHARMACOL, PHARMACOL UNIT, MURCIA, SPAIN

[2] CSV ARRIXACA, DEPT NUCL MED, MURCIA, SPAIN

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1990年 / 21卷 / 05期

关键词：

D O I：

10.1016/0306-3623(90)91036-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. i.c.v. morphine administration (50 μg/10 μl) to sham-lesioned guinea-pigs produces a decrease of body temperature 90 min after injection. 2. This effect was blocked in animals that received i.c.v. 6-OHDA injections 20 days before. 3. On the other hand, morphine injection to sham-lesioned guinea-pigs resulted 30 and 90 min later in suppressed plasma B-END and cortisol concentration. 4. This suppressive effect was increased 20 days after 6-OHDA injections. 5. These results indicate that in the guinea-pig the effects of morphine on both body temperature and plasma levels of B-END and cortisol are altered by hypothalamic DA lesions, and suggest that hypothalamic DA neurons would be one of the sites participating in morphine-induced delayed decreased in plasma B-END and cortisol. © 1990.

引用

页码：799 / 803

页数：5

共 29 条

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