NOVEL AMINOGLYCOSIDE-MODIFYING ENZYME FROM A CLINICAL ISOLATE OF ACINETOBACTER

被引：13

作者：

DOWDING, JE ^{[1
]}

机构：

[1] UNIV LEICESTER, DEPT BIOCHEM, LEICESTER LE1 7RH, W YORKSHIRE, ENGLAND

来源：

JOURNAL OF GENERAL MICROBIOLOGY | 1979年 / 110卷 / JAN期

关键词：

D O I：

10.1099/00221287-110-1-239

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A strain of Acinetobacter that possesses a novel aminoglycoside-modifying enzyme of restricted substrate range is described. The enzyme appears to catalyze the N-acetylation of only those aminoglycosides of the kanamycin-gentamicin group which bear a 2''-hydroxyl group.

引用

页码：239 / 241

页数：3

共 5 条

[1] MECHANISMS OF ANTIBIOTIC-RESISTANCE IN BACTERIA
BENVENISTE, R
DAVIES, J
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1973, 42 : 471 - 506
[2] PLASMID-MEDIATED AMINOGLYCOSIDE PHOSPHOTRANSFERASE OF BROAD SUBSTRATE RANGE THAT PHOSPHORYLATES AMIKACIN
COURVALIN, P
DAVIES, J
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1977, 11 (04) : 619 - 624
[3] MECHANISMS OF GENTAMICIN RESISTANCE IN STAPHYLOCOCCUS-AUREUS
DOWDING, JE
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1977, 11 (01) : 47 - 50
[4] Haas M J, 1975, Methods Enzymol, V43, P611
[5] SHAW WV, 1967, J BIOL CHEM, V242, P687

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