AMINOALKYLATION OF METAL DERIVATIVES OF INDOLE .3. ALKYLATION OF LITHIO-DERIVATIVES OF N-SUBSTITUTED INDOLES WITH 1-CHLORO-2-DIMETHYL-AMINOETHANE

被引：15

作者：

GANELLIN, CR

RIDLEY, HF

机构：

[1] Smith Kline and French Research Institute, Welwyn Garden City, Hertfordshire

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 11期

关键词：

D O I：

10.1039/j39690001537

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Methyl- and 1-phenyl-indolyl-lithium, when treated with 1-chloro-2-dimethylaminoethane, underwent amino-alkylation at the 2-position of the indole nucleus whereas the lithio-derivatives of 1-benzyl- and 1-benzyl-3-phenyl-indole yielded products derived by substitution at the α-position of the benzyl group. The structures of the amines were confirmed by 1H n.m.r. spectra and by hydrogenolysis experiments. The syntheses of 1-phenyl- and 1-benzyl-3-phenyl-indoles are described.

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页码：1537 / &

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