APAMIN, A SELECTIVE SK POTASSIUM CHANNEL BLOCKER, SUPPRESSES REM-SLEEP WITHOUT A COMPENSATORY REBOUND

被引:21
作者
BENINGTON, JH
WOUDENBERG, MC
HELLER, HC
机构
[1] Department of Biological Sciences, Stanford University, Stanford
关键词
SLEEP FUNCTION; SLEEP HOMEOSTASIS; INTRACEREBROVENTRICULAR; SLEEP DEPRIVATION; POTASSIUM TRANSPORT;
D O I
10.1016/0006-8993(95)00591-D
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To determine the role of neuronal potassium conductance in rapid-eye-movement (REM)-sleep homeostasis, we have administered small doses of apamin (2-5 ng), a selective blocker of the calcium-dependent SK potassium channel, injected into the lateral ventricle in rats, and characterized the resultant effects on REM-sleep expression. Apamin produces a dose-dependent reduction in REM-sleep expression without an increase in the frequency of attempts to enter REM sleep, suggesting that accumulation of REM-sleep propensity is suppressed. The vast majority (84-95%) of lost REM sleep is not recovered 40 h after apamin administration. These findings suggest that accumulation of REM-sleep propensity is linked to the increased neuronal potassium conductance in nonREM sleep.
引用
收藏
页码:86 / 92
页数:7
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