ORAL LEUKOPLAKIA: CLINICAL, HISTOPATHOLOGIC, AND MOLECULAR FEATURES AND THERAPEUTIC APPROACH

被引：28

作者：

Martorell-Calatayud, A. ^{[1
]}

Botella-Estrada, R. ^{[1
]}

Bagan-Sebastian, J. V. ^{[2
]}

Sanmartin-Jimenez, O. ^{[1
]}

Guillen-Barona, C. ^{[1
]}

机构：

[1] Fdn Inst Valenciano Oncol, Serv Dermatol, Valencia, Spain

[2] Univ Valencia, Consorcio Hosp Gen, Serv Estomatol, Valencia, Spain

来源：

ACTAS DERMO-SIFILIOGRAFICAS | 2009年 / 100卷 / 08期

关键词：

leukoplakia; tobacco; therapy; risk of transformation;

D O I：

10.1016/S0001-7310(09)72280-X

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Dermatology departments are currently seeing an increase in the number of cases of oral diseases. Of note among the range of lesions covered by this broad area of knowledge is oral leukoplakia-the most common precancerous lesion and the most problematic in terms of both diagnosis and therapeutic management. In addition to defining leukoplakia, this review also establishes a differential diagnosis with the other most important oral diseases and analyzes the different clinical, histologic, and molecular features that can provide an indication of the risk of malignant transformation. Finally, a therapeutic algorithm is presented to help us optimize clinical management of the disease.

引用

页码：669 / 684

页数：16

共 95 条

[1] Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: Correlation with microvessel density, progression, and prognosis [J].

Arora, S ;

Kaur, J ;

Sharma, C ;

Mathur, M ;

Bahadur, S ;

Shukla, NK ;

Deo, SVS ;

Ralhan, R .

CLINICAL CANCER RESEARCH, 2005, 11 (06) :2272-2284

[2] Oral white lesions with special reference to precancerous and tobacco related lesions: Conclusions of an international symposium held in Uppsala, Sweden, May 18-21 1994 [J].

Axell, T ;

Pindborg, JJ ;

Smith, CJ ;

vanderWaal, I .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1996, 25 (02) :49-54

[3]

Bagan JV, 2008, MED ORAL PATOL ORAL, V13, pE110

[4] Lack of association between proliferative verrucous leukoplakia and human papillomavirus infection [J].

Bagan, Jose V. ;

Jimenez, Yolanda ;

Murillo, Judith ;

Gavalda, Carmen ;

Poveda, Rafael ;

Scully, Crispian ;

Alberola, Trinidad M. ;

Torres-Puente, Manuela ;

Perez-Alonso, Manuel .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2007, 65 (01) :46-49

[5] Identification of genes and molecular pathways involved in the progression of premalignant oral epithelia [J].

Banerjee, AG ;

Bhattacharyya, I ;

Vishwanatha, JK .

MOLECULAR CANCER THERAPEUTICS, 2005, 4 (06) :865-875

[6] OCCURRENCE OF EPITHELIAL DYSPLASIA IN ORAL LEUKOPLAKIA [J].

BANOCZY, J ;

CSIBA, A .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1976, 42 (06) :766-774

[7] FOLLOW-UP STUDIES IN ORAL LEUKOPLAKIA [J].

BANOCZY, J .

JOURNAL OF MAXILLOFACIAL SURGERY, 1977, 5 (01) :69-75

[8]

Banoczy J, 2001, J Dent Educ, V65, P322

[9] Gene expression of differentiation-specific keratins in oral epithelial dysplasia and squamous cell carcinoma [J].

Bloor, BK ;

Seddon, SV ;

Morgan, PR .

ORAL ONCOLOGY, 2001, 37 (03) :251-261

[10]

Boned-Blas P, 2002, ACTA DERMOSIFILIOGR, V93, P38

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