GENE-THERAPY UTILIZING DRUG-RESISTANCE GENES - A REVIEW

被引：27

作者：

BANERJEE, D ^{[1
]}

ZHAO, SC ^{[1
]}

LI, MX ^{[1
]}

SCHWEITZER, BI ^{[1
]}

MINEISHI, S ^{[1
]}

BERTINO, JR ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR, MOLEC PHARMACOL & THERAPEUT PROGRAM, 1275 YORK AVE, NEW YORK, NY 10021 USA

来源：

STEM CELLS | 1994年 / 12卷 / 04期

关键词：

DRUG RESISTANCE GENES; GENE TRANSFER; CHEMOTHERAPY; STEM CELLS;

D O I：

10.1002/stem.5530120404

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.

引用

页码：378 / 385

页数：8

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